{"id":9167,"date":"2025-09-23T22:26:53","date_gmt":"2025-09-23T22:26:53","guid":{"rendered":"https:\/\/atlasemhematologia.com.br\/?p=9167"},"modified":"2026-03-24T20:10:49","modified_gmt":"2026-03-24T20:10:49","slug":"anemia-sideroblastica","status":"publish","type":"post","link":"https:\/\/atlasemhematologia.com.br\/blog\/anemia-sideroblastica\/","title":{"rendered":"ANEMIA SIDEROBL\u00c1STICA"},"content":{"rendered":"\n

A anemia siderobl\u00e1stica \u00e9 uma anemia refrat\u00e1ria caracterizada pela presen\u00e7a de “sideroblastos em anel” na medula \u00f3ssea, que s\u00e3o eritroblastos com ac\u00famulo de ferro sob a forma de gr\u00e2nulos dispostos ao redor do n\u00facleo. Isso ocorre devido \u00e0 incapacidade dos eritroblastos de incorporar o ferro ao grupo heme, provocando o seu ac\u00famulo dentro das mitoc\u00f4ndrias e prejudicando a produ\u00e7\u00e3o de hemoglobina.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

As inclus\u00f5es de ferro tamb\u00e9m podem ser observadas nos eritr\u00f3citos mais maduros e s\u00e3o chamadas de corpos de Pappenheimer (ou sider\u00f3citos). A deposi\u00e7\u00e3o de ferro mitocondrial ocorre devido a uma altera\u00e7\u00e3o na s\u00edntese do heme nas c\u00e9lulas eritroides da medula \u00f3ssea, seja pela diminui\u00e7\u00e3o da produ\u00e7\u00e3o de protoporfirina ou pela inser\u00e7\u00e3o defeituosa do ferro na mesma. Os mecanismos que d\u00e3o origem \u00e0s diferentes anemias siderobl\u00e1sticas s\u00e3o diversos, mas em todas elas a s\u00edntese do heme \u00e9 defeituosa.<\/p>\n\n\n\n

\"anemia
corp\u00fasculos de pappenheimer \u2013 Inclus\u00f5es azul\/roxas irregulares Fonte: CellWiki Dispon\u00edvel em: https:\/\/www.cellwiki.net\/en\/aberrations\/erythrocytes-pappenheimer<\/em>
<\/figcaption><\/figure>\n\n\n\n

A anemia frequentemente \u00e9 a \u00fanica manifesta\u00e7\u00e3o dessa doen\u00e7a; portanto, os achados laboratoriais s\u00e3o a base para o diagn\u00f3stico das anemias siderobl\u00e1sticas. Entre os achados principais destacam-se: anemia microc\u00edtica, normoc\u00edtica ou macroc\u00edtica, presen\u00e7a de sideroblastos em anel na an\u00e1lise da medula \u00f3ssea e evid\u00eancia de sobrecarga sist\u00eamica de ferro.<\/p>\n\n\n\n

Na anemia siderobl\u00e1stica, os n\u00edveis de hemoglobina geralmente est\u00e3o abaixo de 7 g\/dL no momento do diagn\u00f3stico, enquanto os leuc\u00f3citos e plaquetas geralmente est\u00e3o dentro dos valores normais, sendo mais severas nas formas heredit\u00e1rias do que nas adquiridas. Os pacientes com a forma autoss\u00f4mica recessiva ligada ao cromossomo X geralmente apresentam anemia grave na inf\u00e2ncia e quase sempre necessitam de suporte transfusional cont\u00ednuo. A maioria est\u00e1 clinicamente associada \u00e0 reticulocitopenia, eritropoiese ineficaz e sobrecarga secund\u00e1ria de ferro.<\/p>\n\n\n\n

Em resumo, A anemia siderobl\u00e1stica \u00e9 uma condi\u00e7\u00e3o hematol\u00f3gica complexa caracterizada pela acumula\u00e7\u00e3o de sideroblastos na medula \u00f3ssea. As principais altera\u00e7\u00f5es observadas no hemograma incluem anemia microc\u00edtica, a presen\u00e7a de sideroblastos anelados e reticulocitopenia. O reconhecimento precoce dessas altera\u00e7\u00f5es no hemograma \u00e9 crucial para o diagn\u00f3stico e manejo adequados dessa condi\u00e7\u00e3o.<\/p>\n\n\n\n

Refer\u00eancias<\/strong><\/h3>\n\n\n\n

RAM\u00cdREZ-IZCOA, Alejandro et al. Anemia siderobl\u00e1stica<\/a>. Revista de Hematologia, 2016.<\/p>\n\n\n\n

Doen\u00e7as que alteram os exames hematol\u00f3gicos \/ Fl\u00e1vio Augusto Naoum. – 2. ed. Rio de Janeiro: Atheneu, 2017<\/p>\n","protected":false},"excerpt":{"rendered":"

A anemia siderobl\u00e1stica \u00e9 uma anemia refrat\u00e1ria caracterizada pela presen\u00e7a de “sideroblastos em anel” na medula \u00f3ssea, que s\u00e3o eritroblastos com ac\u00famulo de ferro sob a forma de gr\u00e2nulos dispostos ao redor do n\u00facleo. Isso ocorre devido \u00e0 incapacidade dos eritroblastos de incorporar o ferro ao grupo heme, provocando o seu ac\u00famulo dentro das mitoc\u00f4ndrias […]<\/p>\n","protected":false},"author":3,"featured_media":9170,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-9167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anemias"],"yoast_head":"\nANEMIA SIDEROBL\u00c1STICA - Blog - Atlas em Hematologia<\/title>\n<meta name=\"description\" content=\"A anemia siderobl\u00e1stica \u00e9 uma anemia refrat\u00e1ria caracterizada pela presen\u00e7a de "sideroblastos em anel" na medula \u00f3ssea, que s\u00e3o eritroblastos\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/atlasemhematologia.com.br\/blog\/anemia-sideroblastica\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ANEMIA SIDEROBL\u00c1STICA - 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