{"id":10120,"date":"2025-09-23T22:25:16","date_gmt":"2025-09-23T22:25:16","guid":{"rendered":"https:\/\/atlasemhematologia.com.br\/?p=10120"},"modified":"2026-03-24T20:45:14","modified_gmt":"2026-03-24T20:45:14","slug":"blastos-cup-like","status":"publish","type":"post","link":"https:\/\/atlasemhematologia.com.br\/blog\/blastos-cup-like\/","title":{"rendered":"BLASTOS CUP LIKE"},"content":{"rendered":"\n

Os blastos com cup-like s\u00e3o uma variante morfol\u00f3gica, obviamente estando associados a presen\u00e7a de blastos, trata-se de um achado importante, pois mesmo n\u00e3o sendo uma caracter\u00edstica espec\u00edfica, pode apontar para certos tipos de leucemias. Sua morfologia caracter\u00edstica \u00e9 semelhante a uma ta\u00e7a ou c\u00e1lice, com um formato c\u00f4ncavo e irregular ocorrendo nas leucemias agudas, como na leucemia mieloide aguda (LMA):<\/p>\n\n\n\n

\"\"
Blastos com invagina\u00e7\u00e3o nuclear cup-like<\/em><\/figcaption><\/figure>\n\n\n\n

Essa altera\u00e7\u00e3o morfol\u00f3gica resulta do ac\u00famulo de organelas citoplasm\u00e1ticas devido a modifica\u00e7\u00f5es no transporte nuclear do NPM1. A microscopia eletr\u00f4nica revela a presen\u00e7a de um agrupamento de mitoc\u00f4ndrias dentro da bolsa nuclear invaginada, que comprime parcialmente a cromatina.<\/p>\n\n\n\n

A morfologia “cup-like” est\u00e1 associada a muta\u00e7\u00f5es proeminentes nos genes NPM1 e FLT3-ITD, na LMA com blastos de morfologia cup-like” ocorre frequente associa\u00e7\u00e3o entre a muta\u00e7\u00f5es no gene da nucleofosmina (NPM1) e no receptor de tirosina quinase semelhante ao FMS (FLT3). Al\u00e9m disso, esses blastos s\u00e3o frequentemente negativos para CD34 e HLA-DR e apresentam cari\u00f3tipo (CTG) normal..<\/p>\n\n\n\n

Existem estudos que correlacionam muta\u00e7\u00f5es do NPM1 e caracter\u00edsticas morfol\u00f3gicas nucleares distintas, como “cup-like” sugerindo que essas caracter\u00edsticas morfol\u00f3gicas podem ser \u00fateis na previs\u00e3o de altera\u00e7\u00f5es moleculares que s\u00e3o prognosticamente significativas. Com isso, esse achado pode ser bastante  \u00fatil. Por esse motivo \u00e9 fundamental o relato dos blastos \u201ccup-like\u201d no hemograma. A compreens\u00e3o das caracter\u00edsticas desses blastos e sua implica\u00e7\u00e3o no diagn\u00f3stico e no progn\u00f3stico pode ajudar na pr\u00e1tica cl\u00ednica. <\/p>\n\n\n\n

<\/h3>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

Refer\u00eancias<\/strong><\/h3>\n\n\n\n

SILVA, A. J. et al. ASSOCIA\u00c7\u00c3O ENTRE BLASTOS CUP-LIKE E A MUTA\u00c7\u00c3O DO NPM1: RELATO DE CASO. Hematology, Transfusion and Cell Therapy, v. 42, p. 142-143, 2020.<\/p>\n\n\n\n

KROSCHINSKY, Frank P. et al. Leucemia mieloide aguda em forma de ta\u00e7a: nova doen\u00e7a ou fen\u00f4meno artificial?. Haematologica , v. 93, n. 2, p. 283-286, 2008.<\/p>\n\n\n\n

BENNETT, John M. et al. A associa\u00e7\u00e3o de n\u00facleos \u201cem forma de x\u00edcara\u201d com muta\u00e7\u00e3o do gene NPM1 na leucemia mieloide aguda \u00e9 clinicamente \u00fatil?. American journal of clinical pathogenic , v. 134, n. 4, p. 648-652, 2010.<\/p>\n","protected":false},"excerpt":{"rendered":"

Os blastos com cup-like s\u00e3o uma variante morfol\u00f3gica, obviamente estando associados a presen\u00e7a de blastos, trata-se de um achado importante, pois mesmo n\u00e3o sendo uma caracter\u00edstica espec\u00edfica, pode apontar para certos tipos de leucemias. Sua morfologia caracter\u00edstica \u00e9 semelhante a uma ta\u00e7a ou c\u00e1lice, com um formato c\u00f4ncavo e irregular ocorrendo nas leucemias agudas, como […]<\/p>\n","protected":false},"author":3,"featured_media":10121,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[13],"tags":[],"class_list":["post-10120","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-celulas"],"yoast_head":"\nBLASTOS CUP LIKE - Blog - Atlas em Hematologia<\/title>\n<meta name=\"description\" content=\"Os blastos com cup-like s\u00e3o uma variante morfol\u00f3gica, obviamente estando associados a presen\u00e7a de blastos, trata-se de um achado\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/atlasemhematologia.com.br\/blog\/blastos-cup-like\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BLASTOS CUP LIKE - 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