{"id":10100,"date":"2025-09-23T22:25:16","date_gmt":"2025-09-23T22:25:16","guid":{"rendered":"https:\/\/atlasemhematologia.com.br\/?p=10100"},"modified":"2026-03-24T20:47:38","modified_gmt":"2026-03-24T20:47:38","slug":"celulas-harlequim","status":"publish","type":"post","link":"https:\/\/atlasemhematologia.com.br\/blog\/celulas-harlequim\/","title":{"rendered":"C\u00c9LULAS DE HARLEQUIM"},"content":{"rendered":"\n

As c\u00e9lulas harlequim s\u00e3o uma forma rara e not\u00e1vel de altera\u00e7\u00e3o celular observada na hematologia. Estas c\u00e9lulas se caracterizam pela presen\u00e7a de gr\u00e2nulos basof\u00edlicos no citoplasma de eosin\u00f3filos, al\u00e9m dos tradicionais gr\u00e2nulos alaranjados desta c\u00e9lula, este achado apesar de exuberante, caracteriza um achado displ\u00e1sico.<\/p>\n\n\n\n

A presen\u00e7a dessas c\u00e9lulas pode ocorrer na leucemia mieloide aguda, assim como na variante eosinof\u00edlica LMA-M4, especialmente quando associada a anormalidades citogen\u00e9ticas recorrentes, como a transloca\u00e7\u00e3o CBFB-MYH11, invers\u00e3o inv(16)(p13.1q22) ou transloca\u00e7\u00e3o t(16;16)(q13.1;q22). Estas altera\u00e7\u00f5es citogen\u00e9ticas s\u00e3o conhecidas por estarem associadas a subtipos espec\u00edficos de LMA. Alguns escritos ainda citam que sua presen\u00e7a pode ocorrer na Leucemia Mieloide Cr\u00f4nica.<\/p>\n\n\n\n

O aparecimento das c\u00e9lulas de harlequim no hemograma de pacientes com s\u00edndrome hipereosinof\u00edlica prim\u00e1ria, em conjunto com sintomas apresentados pode ser um indicativo precoce de uma leucemia mieloide aguda (LMA) ou leucemia eosinof\u00edlica, sendo assim \u00e9 importante observar e relatar esse tipo de anormalidade.<\/p>\n\n\n\n

\"c\u00e9lulas
C\u00e9lulas de harlequin. Fonte: Hemoclass<\/em><\/figcaption><\/figure>\n\n\n\n

A apar\u00eancia irregular dessas c\u00e9lulas e as poss\u00edveis altera\u00e7\u00f5es associadas destacam a import\u00e2ncia da an\u00e1lise detalhada das c\u00e9lulas sangu\u00edneas e da medula \u00f3ssea. A identifica\u00e7\u00e3o de c\u00e9lulas harlequim pode auxiliar no diagn\u00f3stico, progn\u00f3stico e tratamento de v\u00e1rias doen\u00e7as hematol\u00f3gicas, localizadas ou sist\u00eamicas.<\/p>\n\n\n\n

<\/h3>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

Refer\u00eancias: <\/strong><\/h3>\n\n\n\n

RODRIGUES, J\u00falia Morales; BIBERG, Camila. Significado cl\u00ednico de \u201cHarlequin cell\u201d na s\u00edndrome hipereosinof\u00edlica prim\u00e1ria: estudo de revis\u00e3o. Revista Multidisciplinar em Sa\u00fade, 2021.<\/p>\n\n\n\n

Vahedi A, Madani T, Gharib B, Poopak B. ‘Harlequin cells’ in lymphocyte-variant hypereosinophilia. EJHaem. 2022 PMID: 36467787<\/p>\n\n\n\n

ASH PUBLICATIONS. Harlequin cells. Blood, v. 132, n. 7, p. 766, 2018. Dispon\u00edvel em: https:\/\/lnkd.in\/dj9YgMJZ<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

As c\u00e9lulas harlequim s\u00e3o uma forma rara e not\u00e1vel de altera\u00e7\u00e3o celular observada na hematologia. Estas c\u00e9lulas se caracterizam pela presen\u00e7a de gr\u00e2nulos basof\u00edlicos no citoplasma de eosin\u00f3filos, al\u00e9m dos tradicionais gr\u00e2nulos alaranjados desta c\u00e9lula, este achado apesar de exuberante, caracteriza um achado displ\u00e1sico. A presen\u00e7a dessas c\u00e9lulas pode ocorrer na leucemia mieloide aguda, assim […]<\/p>\n","protected":false},"author":3,"featured_media":10104,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[13],"tags":[],"class_list":["post-10100","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-celulas"],"yoast_head":"\nC\u00c9LULAS DE HARLEQUIM - Blog - Atlas em Hematologia<\/title>\n<meta name=\"description\" content=\"As c\u00e9lulas harlequim s\u00e3o uma forma rara e not\u00e1vel de altera\u00e7\u00e3o celular observada na hematologia. 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