{"id":10076,"date":"2025-09-23T22:27:07","date_gmt":"2025-09-23T22:27:07","guid":{"rendered":"https:\/\/atlasemhematologia.com.br\/?p=10076"},"modified":"2026-03-24T20:00:50","modified_gmt":"2026-03-24T20:00:50","slug":"anemia-perniciosa","status":"publish","type":"post","link":"https:\/\/atlasemhematologia.com.br\/blog\/anemia-perniciosa\/","title":{"rendered":"ANEMIA PERNICIOSA"},"content":{"rendered":"\n

A anemia perniciosa \u00e9 uma condi\u00e7\u00e3o que a princ\u00edpio \u00e9 autoimune, caracterizada pela defici\u00eancia de vitamina B12, essencial para a produ\u00e7\u00e3o dos eritr\u00f3citos, e funcionamento do sistema nervoso. a anemia perniciosa \u00e9 a causa mais frequente de d\u00e9ficit de vitamina B12 nos pa\u00edses ocidentais. A les\u00e3o histol\u00f3gica sustentada \u00e9 a gastrite cr\u00f4nica atr\u00f3fica autoimune. A destrui\u00e7\u00e3o das c\u00e9lulas parietais provoca um d\u00e9ficit do fator intr\u00ednseco, prote\u00edna fundamental para que a vitamina B12 seja absorvida no \u00edleo terminal.<\/p>\n\n\n\n

Altera\u00e7\u00f5es Cl\u00ednicas<\/strong><\/h3>\n\n\n\n

Os principais sintomas incluem: Astenia, palpita\u00e7\u00f5es, sudorese, tontura e insufici\u00eancia card\u00edaca de in\u00edcio lento, com boa toler\u00e2ncia pelo paciente. Os dist\u00farbios digestivos incluem anorexia, diarreia, estomatite angular, l\u00edngua lisa e despapilada, dolorosa ao toque e uma cor vermelha intensa chamada glossite de Hunter.<\/p>\n\n\n\n

Altera\u00e7\u00f5es Laboratoriais<\/strong><\/h3>\n\n\n\n

A principal altera\u00e7\u00e3o ocorre no hemograma com macrocitose quando o volume corpuscular m\u00e9dio \u00e9 elevado (> 100) e, portanto, s\u00e3o observados eritr\u00f3citos grandes no sangue perif\u00e9rico ocorrendo justamente pela s\u00edntese anormal de DNA a partir de precursores eritr\u00f3ides e mieloides devido a falta de B12, o que d\u00e1 origem a uma hematopoiese ineficaz. Assim a Anemia perniciosa \u00e9 um tipo de Anemia Megalobl\u00e1stica.<\/p>\n\n\n\n

\"anemia
Megal\u00f3citos em anemia Perniciosa. Fonte Cellwiki<\/em><\/figcaption><\/figure>\n\n\n\n

Os exames de interesse diagn\u00f3stico s\u00e3o os n\u00edveis s\u00e9ricos de vitamina B12 (<100 pg\/ml) e \u00e1cido f\u00f3lico (>4 ng\/ml). A determina\u00e7\u00e3o de anticorpos anti-FI (sensibilidade: 66%; especificidade: 95%) e o n\u00edvel s\u00e9rico de gastrina (se dispon\u00edvel) permitem o diagn\u00f3stico de 90-95% dos casos.<\/p>\n\n\n\n

Em conclus\u00e3o, a anemia perniciosa continua a ser um desafio cl\u00ednico significativo devido \u00e0 sua complexidade fisiopatol\u00f3gica e \u00e0 ampla gama de apresenta\u00e7\u00f5es cl\u00ednicas. Esta condi\u00e7\u00e3o, se n\u00e3o tratada adequadamente, pode levar a complica\u00e7\u00f5es graves e at\u00e9 mesmo fatais. No entanto, com um diagn\u00f3stico precoce e um tratamento adequado, incluindo suplementa\u00e7\u00e3o de vitamina B12 e terapias espec\u00edficas, \u00e9 poss\u00edvel gerenciar eficazmente os sintomas, melhorar a qualidade de vida dos pacientes e prevenir danos a longo prazo.<\/p>\n\n\n\n

<\/h3>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

Refer\u00eancias<\/strong><\/h3>\n\n\n\n

NAOUM, Fl\u00e1vio Augusto. Doen\u00e7as que alteram os exames hematol\u00f3gicos. 2. ed. Rio de Janeiro: Atheneu, 2017.<\/p>\n\n\n\n

PAZ, R. de; HERN\u00c1NDEZ-NAVARRO, F. Gest\u00e3o, preven\u00e7\u00e3o e controle da anemia perniciosa. Nutri\u00e7\u00e3o Hospitalar., v. 20, n. 6, p. 433-435, 2005.<\/p>\n","protected":false},"excerpt":{"rendered":"

A anemia perniciosa \u00e9 uma condi\u00e7\u00e3o que a princ\u00edpio \u00e9 autoimune, caracterizada pela defici\u00eancia de vitamina B12, essencial para a produ\u00e7\u00e3o dos eritr\u00f3citos, e funcionamento do sistema nervoso. a anemia perniciosa \u00e9 a causa mais frequente de d\u00e9ficit de vitamina B12 nos pa\u00edses ocidentais. A les\u00e3o histol\u00f3gica sustentada \u00e9 a gastrite cr\u00f4nica atr\u00f3fica autoimune. A […]<\/p>\n","protected":false},"author":3,"featured_media":17084,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-10076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anemias"],"yoast_head":"\nANEMIA PERNICIOSA - Blog - Atlas em Hematologia<\/title>\n<meta name=\"description\" content=\"A anemia perniciosa \u00e9 uma condi\u00e7\u00e3o que a princ\u00edpio \u00e9 autoimune, caracterizada pela defici\u00eancia de vitamina B12, essencial para a produ\u00e7\u00e3o dos\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/atlasemhematologia.com.br\/blog\/anemia-perniciosa\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ANEMIA PERNICIOSA - 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